Adjuvant molecules to fight antibiotic resistance
Antibiotic resistance is a rising clinical and public health challenge worldwide. Multidrug-resistant strains are emerging to the last resort, antibiotics. Researchers from the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru have studied nonantibiotic compounds called antibiotic adjuvants, which target bacterial resistance and can be used in combination with obsolete drugs for an improved therapeutic regime.
“In the growing era of antibiotic resistance and stringent parameters for developing new drugs, it is imperative to look at the obsolete approved antibiotics, target resistance mechanisms to them, and revive their efficacy. Taking inspiration from the prescription of a combination of drugs, ‘antibiotic adjuvants’ targeting these resistance mechanism...